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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
SLC6A6
All Species:
6.36
Human Site:
Y598
Identified Species:
14
UniProt:
P31641
Number Species:
10
Phosphosite Substitution
Charge Score:
-0.1
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
P31641
NP_001127839.1
620
69830
Y598
E
R
E
G
A
T
P
Y
N
S
R
T
V
M
N
Chimpanzee
Pan troglodytes
XP_001157641
620
69651
Y598
E
R
E
G
A
T
P
Y
N
S
R
T
V
M
N
Rhesus Macaque
Macaca mulatta
Q9MYX0
630
70239
G602
Y
R
L
I
S
T
P
G
T
F
K
E
R
I
I
Dog
Lupus familis
XP_533741
630
70351
T604
K
L
G
A
G
P
R
T
V
T
V
N
D
C
D
Cat
Felis silvestris
Mouse
Mus musculus
O35316
621
69837
F598
E
R
E
G
A
T
P
F
H
S
R
V
T
L
M
Rat
Rattus norvegicus
P31643
621
69850
F598
E
R
E
G
A
T
P
F
H
S
R
A
T
L
M
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001521283
733
81919
F711
E
S
E
G
A
T
P
F
C
S
N
G
T
P
N
Chicken
Gallus gallus
NP_001025771
631
71046
L598
R
N
R
E
W
H
S
L
L
P
Q
W
N
F
E
Frog
Xenopus laevis
A7Y2X0
790
87434
K764
K
H
R
G
E
R
Y
K
N
M
I
D
P
L
G
Zebra Danio
Brachydanio rerio
NP_001032750
625
69879
S598
P
Q
E
Y
Q
P
K
S
N
E
L
A
Q
P
L
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
Q9VR07
943
103618
H891
C
G
E
H
H
C
E
H
D
Y
P
E
Q
E
Q
Honey Bee
Apis mellifera
Nematode Worm
Caenorhab. elegans
Sea Urchin
Strong. purpuratus
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Baker's Yeast
Sacchar. cerevisiae
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
98
42.7
58.4
N.A.
93.2
93.7
N.A.
71.2
79.4
34.8
78.5
N.A.
29.1
N.A.
N.A.
N.A.
Protein Similarity:
100
98.3
60.9
72
N.A.
97.4
97.7
N.A.
78.5
88.1
51.9
88.1
N.A.
42.2
N.A.
N.A.
N.A.
P-Site Identity:
100
100
20
0
N.A.
60
60
N.A.
53.3
0
13.3
13.3
N.A.
6.6
N.A.
N.A.
N.A.
P-Site Similarity:
100
100
40
20
N.A.
80
80
N.A.
60
6.6
26.6
20
N.A.
20
N.A.
N.A.
N.A.
Percent
Protein Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
0
0
10
46
0
0
0
0
0
0
19
0
0
0
% A
% Cys:
10
0
0
0
0
10
0
0
10
0
0
0
0
10
0
% C
% Asp:
0
0
0
0
0
0
0
0
10
0
0
10
10
0
10
% D
% Glu:
46
0
64
10
10
0
10
0
0
10
0
19
0
10
10
% E
% Phe:
0
0
0
0
0
0
0
28
0
10
0
0
0
10
0
% F
% Gly:
0
10
10
55
10
0
0
10
0
0
0
10
0
0
10
% G
% His:
0
10
0
10
10
10
0
10
19
0
0
0
0
0
0
% H
% Ile:
0
0
0
10
0
0
0
0
0
0
10
0
0
10
10
% I
% Lys:
19
0
0
0
0
0
10
10
0
0
10
0
0
0
0
% K
% Leu:
0
10
10
0
0
0
0
10
10
0
10
0
0
28
10
% L
% Met:
0
0
0
0
0
0
0
0
0
10
0
0
0
19
19
% M
% Asn:
0
10
0
0
0
0
0
0
37
0
10
10
10
0
28
% N
% Pro:
10
0
0
0
0
19
55
0
0
10
10
0
10
19
0
% P
% Gln:
0
10
0
0
10
0
0
0
0
0
10
0
19
0
10
% Q
% Arg:
10
46
19
0
0
10
10
0
0
0
37
0
10
0
0
% R
% Ser:
0
10
0
0
10
0
10
10
0
46
0
0
0
0
0
% S
% Thr:
0
0
0
0
0
55
0
10
10
10
0
19
28
0
0
% T
% Val:
0
0
0
0
0
0
0
0
10
0
10
10
19
0
0
% V
% Trp:
0
0
0
0
10
0
0
0
0
0
0
10
0
0
0
% W
% Tyr:
10
0
0
10
0
0
10
19
0
10
0
0
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _